Ized CUmulative Survival trial, SYMPHONY for Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart Events post acute corONary sYndrome, VIGOUR for VIrtual coordinating center for Global collaborative cardiOvascUlar

loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 1998; 83: 280–3. [6] Anker SD, Ponikowski P, Varney S et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet 1997; 349: 1050–3. [7] Cleland JG, Clark AL. Leptin and cardiac cachexia: marker or mediator? Eur Heart J 1998; 19: 1421–2. [8] Poehlman ET, Scheffers J, Gottlieb SS, Fisher ML, Vaitekevicius P. Increased resting metabolic rate in patients with congestive heart failure. Ann Intern Med 1994; 121: 860–2. [9] Eisenhofer G, Friberg P, Rundqvist AA et al. Cardiac function in congestive heart failure. Circulation 1996; 93: 1667–76. [10] Fritsche A, Wahl HG, Metzinger E et al. Evidence for inhibition of leptin secretion by catecholamines in man. Exp Clin Endocrinol Diabetes 1998; 106: 415–8. [11] Böttner A, Eisenhofer G, Torpy DJ et al. Lack of leptin suppression in response to hypersecretion of catecholamines in pheochromocytoma patients. Metabolism 1999; [In Press].